Dean is well-versed with multiple types of firearms; he prefers his Colt 1911 and sawed-off shotgun, but is proficient with most other weapons he might acquire. An expert marksman, he seldom misses his intended target and can efficiently put down anything vulnerable to bullets. As shown in the episode "Frontierland" where he shoots down a phoenix with one shot.
Dean is adept with martial arts and knife fighting as well; he has subdued several human assailants with ease in multiple episodes and bested physically more powerful creatures, often unarmed or equipped with only a blade. In "Nightshifter", he killed a shapeshifter armed with a simple silver letter opener. In "Fresh Blood," he managed to subdue a vampire long enough to inject her with a shot of "dead man's blood." In "The Magnificent Seven," he fought and held off several demons by himself, armed only with a flask of holy water.
Highly resourceful, he frequently utilizes improvised weapons and explosive devices; in "Croatoan," he demonstrated knowledge in chemistry constructing Molotov cocktails and improvised explosive devices, and in "Phantom Traveler," he revealed knowledge of electronics and reverse...

The sixth season picks up a year later after Dean sadly watches Sam sacrificing himself down into the pit. Keeping the promise he made to Sam, Dean gives up the life of hunting and now lives with Lisa and her son Ben. After Dean became poisoned by a Djinn, begins hallucinating his worst fears. Sam saves Dean by injecting him with an antidote and later wakes up seeing Sam alive and well. Sam reluctantly tells Dean that he has been back for nearly a year while hunting with their grandfather, Samuel. After helping kill the Djinns, Dean declines returning to the life of hunting and decides to continue living with Lisa and Ben in order to keep them safe. Lisa tells Dean to return to the life of hunting and she and Ben will be there when he gets back.
In "Live Free or Twi-Hard" Sam and Dean investigate cases of missing girls that are obsessed with vampires. They stake out a bar that eventually leads them to the cause. Dean later crosses paths with a vampire that turns him into one. Expecting to have to be "put down", he goes to visit Lisa, but almost loses control while talking to her and flees. After being cured, he realises that Sam may possibly have let him be turned; but to an...

The fifth season begins right where Season 4 ends with the portal for Lucifer opening. As Lucifer escapes, the brothers are teleported into an airplane by an unknown force (later revealed to be God). Later, Dean is told by Zachariah that he is "Michael's Sword," meaning the Archangel Michael will use his body as a vessel to lead the forces of Heaven against Lucifer, but Dean must consent to this. Dean refuses and Castiel saves him when Zachariah tries to force Dean to agree by harming him and Sam. Bobby gets possessed by a demon and, instead of killing Dean, he kills the demon inside himself, using Ruby's knife, in turn paralyzing himself from the waist down.
In "Good God, Y'All!," Dean and Sam fight War, one of the Four Horsemen of the Apocalypse, in a town where the people think that their neighbors are demons. In this town is Ellen, Jo, and Rufus Turner all trying to hunt the demons, who turn out to be just people that War has made eyes seem black. Once the brothers cut the ring finger off of War, restoring the town to normal, Dean worries that Sam cannot control his urge to drink demon blood, and the brothers agree to go their separate ways because Sam is a liability with...