"Lost: Live Together, Die Alone (#2.23)" (2006)
Desmond: [after Locke smashes the computer] You killed us... you killed us all
Desmond: I love you, Penny.
Desmond: Three days before you came down here, before we met, I heard a banging on the hatch doors, shouting. But it was you John, wasn't it? You say there isn't any purpose, there's no such thing as fate. But you saved my life, brother, so that I could save yours.