I mean, obviously. Chuck/Blair has been a near-constant battle. Games were part of the foundation of their relationship ("You and I bonded over a mutual love of scheming"), games were part of their undoing. Season 2 is inundated with dialogue about games and stakes, winning and losing. Games + Chuck and Blair's king and queen pretensions = every chess and war cliche reference in the history of ever.
Also obviously, games aren't the point. S2's sabotage, schemes, wagers, and ~seductions are just a way for Chuck and Blair to channel their feelings for each other into a safer type of interaction. They lie that the game is what they both enjoy about their relationship, but they're really just afraid to be more than frenemies.
BLAIR: If I say it then Chuck wins.
DAN: But... if you say it then you get him and you win.
BLAIR: No, I lose.
CHUCK: I thought you were ready to tell me how you really felt. Obviously it was just another one of your games.