In resident evil 4,how do you kill the big chief?

You may want to tone down the difficulty, recently tried taking him on on hard mode: epic failure.

I don't know if this helps but I beat him in pro mode with the shotgun. Just kept firing!

just shot him with my sniper....10 times...haha

Buy a rocket launcher (if you have enough money) blast him with it and finish him off with the tmp.

i really dont even think its possible, when i fought him i had 4 first aid sprays most of my guns up to par and a couple of granades (more like 4 or 5) and when i was through with him i had nothing in my inventory i was completly empty.

You can use a hand granade or two when he's on the floor, then when he is unattached to his legs, he'll be hanging on the ceiling and structures, you can go up and start using the shotgun in his face several times.

You can also complete a RGY herb here, I think the red and the yellow are upstairs and the green down next to the entrance.

it totally easy i finished it 100000 times to kill him i kill him easly coz i have alunsher rocket lunsher in one hit he dies in no time colect money to buy lunsher and collect tresures as many how you can then buy rocket lunsher

you need to get a shotgun then look around and you will find shotgun ammo (10) then climb up the ladder get your handgun and right beside the shotgun ammo there will be a herb then climb the ladder where the herb was there will be a tank shot it.(there will be 3 herbs g r y )

Go in “Gun‘s blazing!” simple as that!

It depands on what weapon you have and how much ammo i beat the game a lot of times so now i have the chicago typewriter and the infinete lancher semi auto rifle and trhe mine thrower with billions of dollars