"Rupert, did you call that engineer at Lockheed yet? Well of course you didn't you worthless little... (Hits Rupert the Toy Bear). There, see what you made me do? Do you think I enjoy hitting you? Well actually I do. I enjoy it so much I'm going to do it again!"
"Damn you, vile woman! You've impeded my work since the day I escaped from your wretched womb".
"There's always been a lot of tension between Lois and me. And it's not so much that I want to kill her, it's just, I want her not to be alive anymore".
"What's this? Blueberries? Oh, oh my G...oh, that's better than sex!"
"Who the hell do you think you are?"
The one that I remember is when Stewie is watching some chearleaders changing their clothes in a locker room and quotes, " It appears that my wee-wee has been stricken with rigor-mortis." My favorite, so darn funny.