Imagine Ramona Nowitzky finding about "SHAMY"; she is furious, and decides to "break it up". To that extent, Ramona has some "enhancements" performed. She even drugs Sheldon into almost going to bed with her, but.... here comes Amy Farrah Fowler to the rescue (desguised as
"CATWOMAN", as suggested by Penny), tears poor Ramona apart, and...?