When the girl said their time was unforgettable but it was over now, even though she said she loved him and part of her always wanted him. It's Sookie and Eric from True Blood btw. And all this whil Eric is standing right there, brokenhearted and vulnerable in front of freaking Bill. Just no. Close second is when he she told him she loved him, but loved Bill too. I'm not too upset about it anymore though because I'm confident they'll get back together. But I was pissed off at the time.
This was the most heartbreaking scene because in a way she knows that he loves her and she sort of wants to hear him say it but he thinks that the best thing to do is to just let her go and let her be with the prince and they just gaze into each other's eyes and she think's that he betrayed her but he actually truly loves her and just wanted to be with her.
Rumpelstiltskin and Belle from Once Upon a Time...there are several heartbreaking moments between these 2...and they've only had one full episode together!
I think him believing Regina (I still don't understand why he did so easily) about her being dead was the worst...especially when you learn that Regina's had her locked up all this time :(
And that parting shot Regina gives him after telling him Belle is dead "You should get a new girl". I love Regina but wanted to hit her in that scene!
I think it would be the meadow scene for Freddie/Effy: Effy is slowly going mad and falling deeper into the darkness not being able to handle the explosion of feelings that her love triggered and she finally - for the first time ever - reveals the nature of her problems and talks about her inner demons, how they were chasing her for her entire life and how she was able to hold them back when she shut herself off and built the walls around her heart, but once she opened up to Freddie the walls were gone and it "made her weak", as she explained it. Freddie, a boy who already lost his mother because of the same mental illness, would just listen to her no matter how hard it must have been for him especially after she basically blamed him for triggering her madness (a condition that was actually triggered by numerous psychological problems and issues she had been dealing with for her entire life long before meeting Freddie) and then in a desperate attempt to make her feel better and to show her that he would protect her from everything he runs in the middle of the park chasing away her imaginary "demons" saying that he will fight them. This scene breaks my heart in million pieces and honestly it is the best (imo) scene that Skins could ever come up with despite being a mediorce teen drama with a rather ridiculous plot.
Spike/Buffy shared a heartbreaking scene when Buffy finally told him she loved him and he replied "No, you don't, but thanks for saying it" - it was mostly heartbreaking because she finally opened up to him about her feelings but he rejected it despite being about to die. He chose to die for her like a hero without asking anything in return and without even believing that she ever loved him.
my OTP is Chloe and Oliver from Smallville, and the most heartbreaking scene (at least for me) is towards the end of the Season 10 opener "Lazarus":
it starts at an off-road site, somewhere in the dark. The first we see is just a pair of feet (which belongs to Oliver), then we see two cars (kind of government-issued SUVs) with their headlights on, standing opposite each other at the site. From both cars, two veiled figures, one smaller, one taller (Oliver), start walking towards the opposite car. Right in the middle, they brush each other with the left side, but don't react, just continue to walk. Cut to the inside of the cars, right when the veils fall. The smaller person is revealed as Chloe, who exchanged herself for Oliver. Their expressions, one utterly sad, the other a mix between horror and disbelieving, are so sad that I almost started to cry when I saw that scene. The fact that absolutely no words are spoken during the whole exchange only adds to the fact. I only can recommend to watch that scene for yourself, but be prepared!