Mine is a little different to the spirit of destruction. lol.
I love Darla Dimple from Cats Don't Dance, she's the most phsycotic, violent and freaky child star ever. She's insane, I swear. But soo funny and I just love her!
Ramses from The Prince of Egypt. Yeah, it's true that he's not exactly a villain, but I guess that technically he counts. He's a very well-written, interesting and complex villain and his relationship with Moses is probably my favorite non romantic relationship in an animated movie.