In the series 2 &1/2 men, one of the most vibrant and colorful characters is Rose, who is played by Melanie Lynskey.
Basing a spinoff from 2 1/2 Men seems to be a wonderful idea for Melanie Lynskey. She has certainly paid her dues in the industry.
Possible Plot lines:
Rose has a masters degree in Behavioral Psychology, and as such her patients can supply any degree of humorous situations.
Since we know that Rose, her Father, Brother and Sister own controlling interest in a bank, each of these are possible supporting characters, with a plethora of possible plot lines.
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