Tsunade (綱手) is the Fifth Hokage (五代目火影, Godaime Hokage) of Konohagakure, taking over after Hiruzen Sarutobi died. Along with Orochimaru and Jiraiya, she is one of the Legendary Sannin of Konoha, and the only one left alive after Jiraiya's death and Orochimaru's permanent sealing. She excels in medical ninjutsu.
Bacround Tsunade is the granddaughter of the First Hokage, and the grandniece of the Second Hokage, leading other characters to call her "Princess" (姫, Hime). She is a former student of Hiruzen Sarutobi, along with Jiraiya and Orochimaru. Tsunade is well-known for her extremely large breasts (106 centimeters, according to Jiraiya), despite the fact that Jiraiya referred to her as "flat-chested Tsunade" during their childhood.
During the Second Great Shinobi World War, Tsunade and her former teammates fought Hanzo, who gave them the title of Konoha's "Three Legendary Shinobi" (伝説の三忍, Densetsu no Sannin) as a reward for surviving. On their way back to Konoha, they encountered the Ame Orphans, who Jiraiya chose to train. Throughout the war, she would become famous for frequently counteracting Chiyo's poisoning attempts, earning contempt from Chiyo because of it.
At some point during the war, on her brother's twelfth birthday, Tsunade gave him their grandfather's crystal necklace, in the hopes that it would help him achieve his dream of becoming Hokage. The next day, he died as a casualty of the war, which returned the necklace to Tsunade's possession. Sometime afterwards, Tsunade fell in love with a man named Dan, who also wanted to become Hokage. As a sign of her affection, and in the hopes that it would help make his dreams come true, Tsunade gave him the amulet as well. Dan, too, would go on to die a bloody death during the course of the war, once again returning the necklace to her possession.
With the deaths of the two she loved the most, Tsunade came to lose faith in the title of Hokage, believing that only fools would want such a position. With these changes of ideals, Tsunade left Konoha with Dan's niece, Shizune, taking her in as her apprentice.
The deaths of Dan and Nawaki greatly changed Tsunade; Dan's death, and her failed attempt to save him, gave her hemophobia (a fear of blood), causing her to freeze upon seeing it. The repeated returns of the necklace to her also led her, and many others to believe that it was cursed, and whoever Tsunade might give it to would die soon after.
Tsunade typically projects a tough demeanor, even when facing great personal difficulty, and rarely compliments or praises people. She readily criticizes others for their faults, such as Naruto for his immaturity, or Jiraiya for his perversion, though her habits are rarely any better. On occasion, though, Tsunade shows sympathy for others, consoling Shikamaru that, while he failed his mission to return Sasuke to Konoha, all of his teammates survived. This is also shown when she worked hard in order to help heal Rock Lee, so that he might continue to be a ninja. She also allowed herself to cry when she learned of Jiraiya's death.
Tsunade is also a compulsive gambler, who has the unfortunate disadvantage of having terrible luck. As a result, she has been elevated to a comical status as "The Legendary Sucker" (伝説のカモ, Densetsu no Kamo), for the gross profits others have made off of her misfortune and gambling addiction. In the rare instances that Tsunade hits a winning streak, she believes it to be a bad omen, and bad things do tend to happen to her or her comrades afterwards. The symbol on the back of her coat, 賭 (kake), means "gamble", or "wager", as gambling is one of her favorite pastimes.
As Hokage, Tsunade has shown the same level of loyalty to the village that previous Hokages held; during the invasion of Pain, she released all of her chakra in order to save the lives of hundreds of people within Konoha, at great personal risk. Tsunade also has a great deal of faith in the next generation, and sees the potential that Naruto and the rest of the Konoha 11 hold.
Tsunade has a pet pig, Tonton, that is usually kept in the care of Shizune.
Tsunade using the Creation Rebirth technique.