FBI Agent Henricksen: I, uh... I shot the sheriff.
Dean Winchester: But you didn't shoot the deputy.
FBI Agent Henricksen: Five minutes ago I was fine, and then...
Dean Winchester: Let me guess. Some nasty black smoke jammed itself down your throat?
Sam Winchester: You were possessed.
FBI Agent Henricksen: Possessed, like... possessed?
Sam Winchester: That's what it feels like. Now you know.
Dean Winchester: I owe you the biggest I-told-you-so ever.
Ruby: [after being told that they lost the Colt] I'm sorry, I must have blood in my ear. I thought I just heard you say that you were stupid enough to let the Colt get grabbed out of your thick, clumsy, idiotic hands.
Dean Winchester: This is pretty wild, right? I mean it's like they're coming straight for us. They've never done that before. Like we've got a contract on us. You think it's 'cause we're so awesome? I think it's 'cause we're so awesome.
FBI Agent Henricksen: I got a lot to celebrate. I mean, after all, seein' you two in chains?
Dean Winchester: You kinky son of a bitch. We don't swing that way.
FBI Agent Henricksen: You know what I'm trying to decide?
Dean Winchester: I don't know, what, whether Cialis will help you with your little condition?
Dean Winchester: I'm not going to let the demon kill some sweet innocent girl, that hasn't even been laid yet.
FBI Agent Henricksen: I better call in. Hell of a story I won't be telling.
Sam Winchester: So what are you gonna tell 'em?
FBI Agent Henricksen: The least ridiculous lie I can come up with in the next five minutes.
Dean Winchester: Good luck with that. Not to pressure you or anything, but... what are you planning to do about us?
FBI Agent Henricksen: I'm gonna kill you.
FBI Agent Henricksen: Sam and Dean Winchester were in the chopper when it caught on fire. Nothing's left. Can't even identify 'em with dental records. Rest in peace, guys.
Dean Winchester: Nobody kills any virgins!