#1: MAKE PAYNE 3 - UZI (or Micro SMG if you prefer):
I never played the others. I play Max Payne 3 as it's OWN game.. The 3rd games gives enough to understand the character.. His family is dead, he's rarely serious, he has a serious temper issue, but he's a decent human being, even though he believes he's NOT.
Anyway. Max seems to prefer hand weapons.
In all cutscenes, if your using a shotgun or machine gun, he will hold it in his other hand while holding a handgun as the actual weapon, and after each cut scene you always have to switch back to it. Something that confused the first time, I did the most just HOLDING the bigger gun, till I learned how to switch back.
Any way. Uzi's are good for TWO reasons.
Max holds in the cut scenes you don't have to switch back to it (plus he looks awesome holding it).
Second. It's far more convent than a heavy machine gun. And if you know how to use it properly, it's one of the best guns of the game.
I complete the mission of when your fighting the military guys though the streets JUST with an Uzi.
Along with the most of the mission where your trapped inside the building that later burns down (almost with Max burning with it)..


#2: GTA 4 - CARBINE RIFLE:
The carbine rifle is the gun that you use in the famish bank robbery mission.
I also like the AK47 now that you mention it..


#3: RED DEAD REDEMPTION - WINCHETER:
There's just something about this rifle that I really like, it's probably not even the best gun..


#4: NO MORE HEROES - KANATA (by windwakerguy430):
Wind didn't say anything.. Just gave this link..
link


#5: DEAD RISING 2 - KNIFE GLOVES:
My trademark weapon against bosses :)


#6: GTA 5 - AP PISTOL (with RedRose85):
"Perfect weapon of choice if you need something but don't want anyone else to see it. It can easily be concealed under a shirt. And while it does damage and if you hit the pedestrian in the right spot, it could be lethal." - Rose

For those that don't know, AP pistol is the machine based pistol, first introduced in Lost and Damned, when Johnny and Jim get the dirty cops to chase them so they can lure them into a Lost MC ambush. It's a fun little gun..


#7: DEAD SPACE - LINE GUN (Hardrocker21):
"Initially pretty weak, but once this weapon has been upgraded to full power it can take down powerful foes with relative ease." - Hardrocker21

I don't think I played this game. So don't know much about this weapon..


#8: LEFT 4 DEAD 2 - PUMP SHOTGUN:
Makes me feel like I'm in Walking dead, along with a baseball bat or fireaxe.. My perfect zombie chopping weapons..


#9: LEFT 4 DEAD 1 - ASSULT RIFLE (M16):
Can't go wrong!


#10: LA NOIRE - TOMMY GUN:
It may make the gun fights end up a little too quickly. But it's worth it..