1)Put vervain into the water supply of Mystic Falls,so that when people drink it and he bites someone,he'll become weak
2)Each and every time he asks you a question,say "that's for me to know and for you to dot dot dot."
3)Ask him if he ever had a threesome with his brother and Katherine
4)If he doesn't kill you because of the third one and he syas no,say "how do you know?for all we know,she could have erased the memory from your mind with her hypnotic powers."
5)Throw onions on him
6)Flash your crucifix at him every time you see him
7)Bite him and shout "ooooohhhh!you don't like it?!you do it so much,so I thought I should show you how it feels,you bastard!"
8)When he dances,push him and start a dance battle
9)When he talks,repeat after him;like someone backing him up while snapping your fingers with attitude
AND THE FINAL WAY TO GET DAMON ANNOYED IS...
10)Create a Twitter posing as him and give ALL of his personal information away to his rabid fangirls