Out of all of the superheroes, Batman is the one with the most popular group of villains. Batman may not have superpowers, but his intelligence and skills lead to him fighting more supervillains than most, if not, all superheroes. There's so many Batman villains that it can be difficult to keep track of them all. Naming every villain from every Batman comic is practically an impossible mission, but it is possible to list the major enemies in the Batman franchise.

Main Villains:

Joker (Batman's archenemy)
Penguin
Riddler
Two-Face
Mr. Freeze
Poison Ivy
Scarecrow
Ra's Al Ghul
Talia Al Ghul
Bane

Villains That Have Become Anti-Heroes:
Catwoman
Harley Quinn
Deadshot

Other Important Villains:

Killer Croc
Clayface
Man-Bat
Mad Hatter
Hugo Strange
Ventriloquist/Scarface
Firefly
Hush
Professor Pyg
The Court Of Owls
The Batman Who Laughs
Victor Zsasz
Anarky
Calendar Man
Maxie Zeus
Killer Moth
Kite Man
Polka-Dot Man
Ratcatcher
Dollmaker
Solomon Grundy
Cluemaster
Catman
Black Mask
Carmine Falcone
Sal Maroni
Rupert Thorne
Lew Moxon
Joe Chill
Tony Zucco

Major DC Villains That Occasionally Fight Batman:

Lex Luthor (Superman's archenemy)
Deathstroke (the archenemy of the Teen Titans)
Clock King (a Green Arrow villain)
Gentleman Ghost (a Hawkman villain)
Rag Doll (a Flash villain)